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Sprionolactone is a custom pharmacy drug classified in the family of drugs known as aldosterone receptor antagonists. Sprionolactone is often used in the treatment of heart failure, hyperaldosteronism, edema, and low potassium levels. It may be used in concert with other drugs for the treatment of high blood pressure. Additionally, it is sometimes used to treat puberty issues and abnormal facial hair. Sprionolactone works by stimulating the kidneys to expel unneeded sodium and water from the body.


Sprionolactone should be taken orally as a tablet in most cases. If your doctor orders a different form of this drug, talk to your compounding pharmacist. Sprionolactone is usually given once or twice per day and at the same times of day throughout your course. Always follow your doctor's recommendations and directions exactly. Never take more than your prescribed amount. Consult with your compounding pharmacist if you have further general questions about this drug.

IMPORTANT NOTE: Watch your potassium intake while taking this drug. Talk to your doctor about your diet.

IMPORTANT NOTE: You should avoid all potassium-containing salt substitutes while taking sprionolactone.


Generally speaking, any drug may bring about side effects. Your unique body chemistry will typically be the determining factor as to how your body reacts to any new drug, and unfortunately there is no way to know how any drug will affect you until you begin taking it. With this in mind, it is best to have a consultation with your doctor and discuss all possible side effects so you will know what to watch for, and know how to respond. Common side effects seen with sprionolactone are:

  • Dry Mouth
  • Thirst
  • Vomiting
  • Diarrhea
  • Stomach Pain
  • Stomach Cramps
  • Headache
  • Irregular Menstrual Periods
  • Vaginal Bleeding (post-menopausal, and at the end of monthly menstrual periods)
  • Enlarged or Painful Breasts (men or women)
  • Difficulty Keeping Erection
  • Difficulty Achieving Erection
  • Deepening Voice
  • Increased Hair Growth
  • Restlessness
  • Dizziness
  • Unsteadiness
  • Drowsiness
  • Tiredness

If you experience any side effects that seem to be growing worse or hanging around, see your doctor.

Severe Side Effects:

Some people may experience severe side effects while using sprionolactone. If you find that you are experiencing anything severe or anything listed below, seek medical treatment right away.

  • Burning, Numbness, Tingling or Pain (hands, feet)
  • Inability to Move Arms or Legs
  • Nausea
  • Vomiting Blood
  • Extreme Tiredness
  • Changes in Heartbeat
  • Unusual Bleeding
  • Abnormal Bruising
  • Lack of Energy
  • Loss of Appetite or No Appetite
  • Pain in Upper Right of Stomach
  • Jaundice
  • Decrease in Urination
  • Fainting
  • Flu-Type Symptoms
  • Rash
  • Hives
  • Itching
  • Difficulty Breathing
  • Confusion
  • Difficulty Swallowing
  • Muscle Weakness
  • Pain
  • Cramps
  • Blood in Stool


All patients considering the use of sprionolactone should first consult with their doctor before beginning use. Inform your doctor about your medical history and any medications that you are currently using.

Sprionolactone is contraindicated for the following:

  • Renal Failure
  • Hyperkalemia
  • Hyponatremia
  • Peptic Ulcer

Sprionolactone may be contraindicated for any of the conditions, etc. listed below. Talk to your doctor if any of these are relevant to you:

  • Acute Renal Failure
  • Kidney Disease
  • Severe Renal Impairment
  • Addison's Disease
  • High Potassium Level in Blood
  • Decreased Blood Volume
  • Absence of Urine Formation
  • Hyperchloremic Acidosis
  • Acid Base Problem (with low chloride and basic ph blood)
  • Low Sodium Level in Blood
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA