Protirelin, sometimes branded as Thyrel TRH, is the manufactured analogue of the endogenous peptide thyrotropin-releasing hormone (TRH). Protirelin is released by the hypothalamus. As an important tri-peptide tropic hormone it works to initiate the release of thyroid stimulating hormone (TSH) as well as prolactin (PRL) from the anterior pituitary gland. Specifically, protirelin is produced by select neurons that are activated in the paraventricular nucleus of the hypothalmus and once in circulation, the TSH and PRL are released. Protirelin can be used as a controlled diagnostic testing agent to help doctors assess how well a patient's anterior pituitary gland is performing. This testing is especially useful in patients who may have medical conditions related to the thyroid gland.
Additionally, protirelin may enhance plasma growth hormone concentrations in some patients, specifically those with acromegaly, a disorder that may result from an overproduction of growth hormone, perhaps by benign tumor of the pituitary gland (adenoma).
Protirelin is delivered as an injectable solution. Protirelin is typically available as a 500 mcg/ml intravenous solution. Doctors will make specific dosing recommendations on a case by case basis for individual patients based on multiple factors such as the patient's current medications, conditions that are being treated, response to medication, height, weight, age, and gender. For questions, consult product-packaging directions or consult the manufacturer.
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