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Promethazine is a custom-made pharmacy drug classified in the family of drugs known as phenothiazines. Promethazine is active within the brain; it transforms the specific actions of certain chemicals and substances. As an antihistamine, promethazine is given to treat many types of allergic reactions such as allergic conjunctivitis, allergic rhinitis, external skin reactions, as well as allergic reactions to plasma and blood. Some of the various symptoms that promethazine may relieve are redness, watery eyes, and runny nose. Promethazine is also used to treat the life-threatening allergic reaction known as anaphylaxis, as well as for sedation before and after surgical procedures and during labor, and to control nausea and vomiting often experienced by patients who have recently undergone surgery.


Promethazine is often taken orally as a liquid or tablet, though it can also be given via rectal insertion as a suppository. Varying forms of this drug for cold symptoms, allergy symptoms, motion sickness, sedation, etc. each have their own specific standard dosage and usage requirements; if you are prescribed promethazine, ask your doctor to explain how to use your prescribed form of the drug properly.


Some users may experience no side effects at all, though others might experience one or several side effects. Talk to your doctor about all the possible side effects of promethazine. Knowing what to possibly expect as well as being prepared with the knowledge of how to respond will benefit your health. Common side effects seen with promethazine are:

  • Stuffy Nose
  • Itching
  • Dry Mouth
  • Trouble Staying Asleep
  • Difficulty Falling Asleep
  • Nightmares
  • Feeling Drowsy
  • Feeling Listless
  • Dizziness
  • Ringing in Ears
  • Double Vision
  • Blurred Vision
  • Loss of Coordination
  • Nausea and/or Vomiting
  • Hyperactivity
  • Restlessness
  • Nervousness
  • Abnormal or Overly Happy Mood

Severe Side Effects:

Promethazine is a strong drug and as such can cause unwanted side effects in some users. Some may experience zero side effects while others may experience multiple, sometimes even severe side effects. Unfortunately there is no way to predict how any drug or medication will affect you until your body reacts to it. Talk to your doctor about all possible side effects, common, and severe. Knowing what to expect and how to respond will be very beneficial in the event that you do experience any side effects. Some of the severe side effects that may be possible are listed below. If you experience anything on this list below, or anything that even feels severe but may not be listed, see your doctor right away or get immediate medical treatment at an approved medical facility by a qualified doctor or healthcare provider.

  • Fever
  • Sweating
  • Muscle Stiffness
  • Slowed Breathing
  • Wheezing
  • Breathing that Stops for a Moment or More
  • Decrease in Alertness
  • Accelerated Heartbeat
  • Feeling Faint
  • Irregular Pulse and/or Heartbeat
  • Uncontrollable Movements
  • Inability to Respond to People
  • Unmanageable Fear or Emotion
  • Hallucinations
  • Confusion
  • Seizures
  • Uncontrollable Shaking
  • Unusual Bruising
  • Abnormal Bleeding
  • Fever, Chills, Sore Throat or General Signs of Infection
  • Uncontrolled Eye Movement
  • Tongue Sticking Out or Extending from Mouth
  • Abnormal Neck Position
  • Jaundice
  • Rash
  • Hives
  • Swelling (face, eyes, lips, tongue, throat)
  • Swelling (arms, hands, feet, ankles, lower legs)
  • Difficulty Breathing
  • Trouble Swallowing
  • Hoarseness

Other types of side effects are possible as each person's body chemistry is unique, so if any of the above or any other side effects are experienced, monitor them closely and seek medical attention if you feel it is warranted. Always seek medical attention if any side effects are worsening or lingering.


All patients considering the use of promethazine should first consult with their doctor before beginning use.

Promethazine may be contraindicated for many different medical conditions, issues, diseases, drug interactions, or other reasons. Only your doctor can make the decision as to whether promethazine will be safe for your use. Discuss all contraindications with your doctor. Follow your doctor's recommendations.

Promethazine is contraindicated for the following patients and/or conditions:

  • Comatose States
  • For Treatment of Lower Respiratory Tract Symptoms (including asthma)
  • Hypersensitivity to Promethazine
  • Hypersensitivity to Phenothiazines
  • Pediatric Patients Less Than 2 Years of Age
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA