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Prochlorperazine is a custom pharmacy drug classified in the family of drugs known as conventional antipsychotics. It is also classified as an anti-nausea medication. Prochlorperazine is active within the brain as a control to decrease certain abnormal activity and excitement. Prochlorperazine has multiple uses in modern medicine; the most prevalent uses are for treating extreme nausea and vomiting, as well as for the treatment of schizophrenia.


Most medications can be compounded into various forms, tailored to a patient's specific needs. If your doctor prescribes prochlorperazine for your treatment, talk to him or her about all of the possible forms of delivery to ensure that, together, you decide on a form that is best for you and your condition. Commonly, prochlorperazine is given as a tablet or suppository. Adult dosage of tablets is typically three to four times per day but your doctor will decide the precise dosage based on your condition, health, and age. Suppository usage is typically two insertions per day, but again, your doctor may alter standard usage depending on your health or condition status, etc. Consult with your compounding pharmacist for more information on this drug and its potential benefits. Always follow your doctor's directions for dosage and usage for only a qualified doctor who has intimate knowledge of your health status and medical history can decide if prochlorperazine is safe for your use, or whether it is the best choice of medication for your condition.


Side effects are possible with all drugs and medications. Prochlorperazine may bring on side effects, so be sure to discuss all possible side effects with your doctor at your initial consultation. Remember, it is important to see your doctor if you experience any side effects that hang around/persist, or worsen. Standard side effects that might present during your course of prochlorperazine are as follows:

  • Dry Mouth
  • Stuffy Nose
  • Headache
  • Nausea
  • Constipation
  • Difficulty Urinating
  • Breast Enlargement
  • Breast Milk Output
  • Skipped Menstrual Periods
  • Narrowing of Pupils
  • Widening of Pupils
  • Increase in Appetite
  • Weight Gain
  • Agitation
  • Jitteriness
  • Decreased Sexual Ability (men)
  • Difficulty Falling Asleep
  • Trouble Staying Asleep
  • Blank Expression (face)
  • Drooling
  • Dizziness
  • Feeling Unsteady
  • Balance Problems
  • Blurred Vision
  • Uncontrollable Shaking
  • Shuffling Type Walk

Severe Side Effects:

Some patients using prochlorperazine might experience distressing, severe side effects. Since this is within the realm of possibility, you should be prepared and know what to watch for. If you encounter any side effects that feel severe, or anything listed below, see your doctor right away or get immediate medical assistance.

Partial List of Possible Severe Side Effects:

  • Falling
  • Confusion
  • Accelerated Heartbeat
  • Irregular Heartbeat
  • Sweating
  • Fever
  • Muscle Stiffness
  • Jaundice
  • Flu-Like Symptoms
  • Signs Of Infection
  • Neck Cramps
  • Trouble Swallowing
  • Uncontrollable or Odd Mouth and/or Jaw Movements
  • Worm-Like Tongue Movements
  • Swelling (eyes, face, mouth, lips, tongue, throat)
  • Swelling (arms, hands, feet, ankles, lower legs)
  • Vision Loss (in particular, at night)
  • Brown Tint (vision)
  • Coma
  • Loss of Consciousness
  • Erection (lasting for hours)
  • Seizures
  • Rash
  • Hives
  • Itching
  • Tongue Hanging or Sticking Out of Mouth
  • Tightness in Throat
  • Difficulty Breathing


There may be many possible contraindications for prochlorperazine. Ask your doctor to discuss all contraindications to ensure that this drug is safe for your use. Never take prochlorperazine without the approval of your doctor.

Prochlorperazine is contraindicated for the following patients or conditions:

  • Comatose States
  • Pediatric Surgery
  • Patients Under 2 Years of Age
  • Patients Under 20 Lbs
  • Anyone Taking or Consuming Central Nervous System Depressants
  • Patients with Known Hypersensitivity to Phenothiazines

WARNING: Older patients suffering from dementia-related psychosis should never take prochlorperazine.

WARNING: Ask your doctor about the risk of tardive dyskinesia and neuroleptic malignant syndrome (NMS).

SPECIAL NOTE: Prochlorperazine is, in most cases, contraindicated for pregnancy and breastfeeding. Talk to your doctor and get more information.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA