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Prednisolone is a custom pharmacy drug classified as a corticosteroid. In simplest terms, prednisolone is a steroid that stops the body from releasing certain substances that can cause inflammation. Prednisolone attends to the symptoms that occur when corticosteroid levels are low. It effectively creates a change within the body's immune system and is a useful drug for treating multiple conditions. Prednisolone is often given as part of a treatment protocol for conditions that affect the skin, blood, kidneys, eyes, stomach, central nervous system, lungs, and intestines. Additionally, some physicians prescribe prednisolone for various allergic reactions, arthritis, and multiple sclerosis. Prednisolone is given to patients who have recently received transplanted organs, to help minimize the risk of the body rejecting their new organ.


Prednisolone is typically taken orally, several times a day as prescribed by your physician. It comes in different forms, which allows your physician to match a particular form of delivery to your unique needs as a patient. Prednisolone may be compounded as a standard tablet, orally disintegrating tablet, a suspension, and as a solution. It is recommended to take this drug with food. Take this drug exactly as directed by your physician and never change your dosage or schedule without approval from her or him. Your compounding pharmacist is always available to answer questions about the drug and its properties, effects, etc.


Drugs and medications, as well as supplements, can bring about troubling side effects in some patients. Sometimes the side effects are easily tolerated and go away quickly after the body adjusts; however, sometimes side effects can be protracted. It is very important to have a frank discussion with your physician about all possible side effects that you may experience while taking prednisolone in order to know what to watch for, how to respond, and when to get emergency medical assistance. Some users of prednisolone may be fortunate and experience zero side effects, but anyone taking this or any other drug should be aware of the possibilities. Common side effects are listed below. Please note that common side effects may dissipate and be no cause for concern, but in some cases these common side effects may linger or get worse, if they do, see your doctor. Always get emergency medical attention right away if you experience anything that feels severe or is very concerning.

Partial List of Common Side Effects:

  • Extreme Changes in Mood
  • Feeling Excited and/or Unusual Happiness
  • Personality Changes
  • Trouble Staying Asleep
  • Difficulty Falling Asleep
  • Irregular Menstrual Periods
  • Skipped Menstrual Periods
  • Thin Skin
  • Slowed Wound Healing
  • Acne
  • Headache
  • Nausea
  • Thinning Hair
  • Increased Appetite
  • Body Changes
  • Increased Sweating

Severe Side Effects:

Some patients taking this drug may experience severe side effects. Severe side effects are potentially dangerous and require attention by qualified medical professionals. If you experience anything severe, see your doctor at once. If your doctor is unavailable, get emergency medical treatment right away. Some of the more common severe side effects are as follows:

  • Signs of Infection
  • Fever
  • Sore Throat
  • Chills
  • Cough
  • Muscle Weakness
  • Hives
  • Itching
  • Rash
  • Seizures
  • Vision Problems
  • Loss of Contact with Reality
  • Depression
  • Swelling (eyes, face, lips, tongue, throat)
  • Swelling (arms, hands, feet, ankles, lower legs)
  • Sudden Weight Gain
  • Stomach Swelling
  • Trouble Swallowing
  • Difficulty Breathing


Prednisolone is a potent drug and should never be used by anyone unless they have seen their physician and she or he has approved its use for their treatment.

Prednisolone is contraindicated for the following:

  • Peptic Ulcers
  • Osteoporosis
  • Psychoses
  • Infections
  • Diabetes
  • Hypertension

Prednisolone may be contraindicated for many other issues and conditions. Consult with your physician and have a thorough discussion of all possible contraindications that may be relevant to you.

WARNING: Prednisolone may create a dangerous drug interaction when used with certain other medications so it is imperative that you make your physician aware of every drug that you are currently taking or using (including topicals). Also inform your physician of all drugs that you were recently taking but may not be currently taking as drugs can remain in your system for quite some time after you physically stop taking them. Your physician will consider other options for your treatment if he or she decides that prednisolone is not safe for your use.

Never take prednisolone without the approval of your physician.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA