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Pramoxine is a custom pharmacy drug that is classified in the family of drugs known as topical anesthetics. As a numbing agent, pramoxine is widely used in medicine due to its effectiveness in regulating, reducing, or eliminating pain signals sent by the nerves to the brain. Pramoxine is often a primary choice for the treatment of many external ailments that may bring about pain and itching such as minor burns, scrapes, skin rashes, dryness, insect bites, hemorrhoids, and chapped lips. Pramoxine is also used to treat poison ivy, poison oak, and poison sumac.


Your compounding pharmacist can prepare and deliver pramoxine in multiple forms for administration. Ask your doctor to review the various forms and consult with him or her about which form of pramoxine would be best for your specific condition or health status. Your compounding pharmacist can craft pramoxine into lotions, creams, foams, gels, and sprays. Additionally, for rectal issues, pramoxine comes as a liquid solution. Pramoxine is typically prescribed for usage several times per day, but your doctor will decide what is best for your specific issue or condition. Always wash and carefully dry the target area before applying. Do not bandage or wrap the affected area unless specifically told to do so by your doctor. Consult with your doctor for information regarding choice of product/delivery form, and usage, and follow her or his directions.

WARNING: Take care to avoid getting any pramoxine into your nose or eyes. If you accidentally get any pramoxine into your eyes, immediately flush thoroughly with water and call your doctor right away.

NOTE: Never use pramoxine on deep wounds, open wounds, or large areas.


Side effects are a possible outcome of any drug or medication use. While many users may feel or experience no side effects at all, others may have a different experience altogether since no two people are the same. Note any side effects and monitor them. If they feel like they are lingering or getting worse, see your doctor. Common side effects seen with pramoxine are:

At Site of Application / Affected Area:

  • Swelling
  • Pain
  • Redness
  • Irritation
  • Burning
  • Stinging
  • Dryness

Severe Side Effects:

Unfortunately, some users may experience severe side effects while using pramoxine. Severe side effects require prompt medical attention, so if you experience anything severe, see your doctor right away or seek immediate medical treatment at a healthcare facility. A partial list of some severe side effects is below.

  • Hoarseness
  • Difficulty Breathing
  • Trouble Swallowing
  • Swelling (face, throat, tongue, lips, eyes)
  • Swelling (hands, feet, ankles, lower legs)
  • Bleeding (at the affected area)
  • Hives
  • Skin Rash
  • Severe Itching


Consult with your doctor before beginning use of any drug or supplement. Only your doctor can decide if pramoxine will be safe for your use, or effective in treating your condition.

There may be many contraindications for the use of pramoxine. Ask your doctor for a complete overview of all possible contraindications.

Pramoxine may be contraindicated for the following:

  • Kidney Disease
  • Osteoporosis
  • Infection caused by Varicella Zoster virus
  • Hypothyroidism
  • Diabetes
  • Mental Disorders
  • Increased Pressure in Eye
  • Wide-Angle Glaucoma
  • High Blood Pressure
  • Untreated Systemic Fungal Infection
  • Large Open Wound
  • Chronic Heart Failure
  • Diverticulitis
  • Active Tuberculosis
  • Herpes Simplex
  • Some Infections (Ask your doctor.)
  • Overactive Thyroid Gland
  • Abnormal Connection Between Stomach and Intestine
  • Surgical Joining of Intestine
  • Measles
  • Intestinal Abscess
  • Allergy to Pramoxine
  • Allergy to Corticosteroids

It is important to have a discussion with your doctor about all your medical conditions, drugs you have taken recently or are currently taking, and any health concerns you may have before using pramoxine in any form.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA