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Piperacillin is a custom-made pharmacy drug that is classified as a penicillin-type antibiotic. Generally speaking, antibiotics have one primary function—to kill bacteria. Piperacillin works, specifically, by stopping the growth of bacteria, preventing it from maturing and flourishing. Piperacillin is utilized in the treatment of many and various bacterial infections. Additionally, it is used before certain surgical procedures to ward off potential infections.


Piperacillin may come in various compound forms, combined with other drugs. Often, it is given as an intravenous injection by a doctor in a clinical setting; however, your doctor may prescribe injections for your use at home. If the latter, be sure that you get proper training on how to correctly administer the drug via injection. If there is anything you are unsure about, ask your doctor or healthcare worker to explain further. Never administer injections to yourself unless you are confident in the procedure and technique.


Any drug can produce some side effects that the patient does not want. Side effects often differ from person to person. Some may experience multiple side effects, one, or none at all. Common side effects seen with piperacillin are:

  • Dizziness
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Other side effects may be possible. Observe your condition closely. Seek medical assistance if any side effects are increasing in intensity and/or persisting (hanging around).

Severe Side Effects:

Some patients using piperacillin could possibly experience severe side effects. Ask your doctor to explain the types of severe side effects that are possible and be prepared to act accordingly if you experience any. Severe side effects can be dangerous. See your doctor immediately or get to a medical treatment facility at once if you experience anything severe. A partial list of some of the known severe side effects is provided below.

  • Irregular Heartbeat
  • Swelling at Injection Site
  • Swelling (arms, legs)
  • Pain at Injection Site
  • Pain (arms, legs)
  • Extreme Tiredness
  • Signs of Infection (fever, sore throat, etc.)
  • Dark Colored Urine
  • Cloudy Urine
  • Bruise Easily
  • Easy Bleeding
  • Kidney Problems or Signs of (change in the amount of urine)
  • Jaundice
  • Seizures
  • Uncontrolled Movements
  • Confusion
  • Muscle Cramps
  • Severe Abdominal Pain
  • Steady or Lingering Nausea and/or Vomiting


All patients considering the use of this drug should first consult with their doctor before beginning use.

Piperacillin may be contraindicated for many conditions. Talk to your doctor about all the possible contraindications for this drug.

Piperacillin may be contraindicated for the conditions listed below. Talk to your doctor if any of the following applies to you:

  • Clostridium Difficile Infection
  • Increased Risk of Bleeding (due to clotting disorder)
  • Decreased Levels of Neutrophils in Blood
  • Allergies to Penicillins and/or Betalactams
  • Low Potassium Levels in Blood
  • Kidney Disease with Reduced Kidney Function
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA