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Niacinamide is a soluble form of niacin, or as it is commonly known—vitamin B3. It is often used for the prevention and treatment of niacin deficiencies that may be due to medical conditions or perhaps dietary issues. As niacinamide is generally considered to be easier to use, with a lower amount of potential side effects than niacin, it is often a preferred drug for the treatment of various medical conditions. Some of the niacin deficiency related conditions that may be treated with niacinamide are as follows: dementia, diarrhea, peeling skin, tongue swelling or redness, and more.

In the anti-aging arena, niacinamide has been hailed as a melanin suppressant. High levels of melanin in the skin may be the root cause for unwanted skin issues such as freckles, age spots, and hyper-pigmentation, wrinkles, fine lines, blotchiness, and yellowing. Niacinamide may also, in some users, improve skin elasticity that will aid in firming the skin for a more youthful look.


For conditions requiring an oral treatment of niacinamide, it is often given one to two times per day, or as directed by a doctor. If you are prescribed an extended-release capsule, never chew or bite into the capsule as this could cause too much of the drug to be released at once. If you are given a prescription of tablets, take the whole tablet, never split them unless specifically told to do so by your doctor, or compounding pharmacist who is aware of your medical condition and your doctor's recommendations.

For topical skin care treatment, use the prescribed product according to packaging instructions unless given other instructions specifically by your primary care doctor who is attuned to your treatment protocol.

Always follow your doctor's instruction and directions precisely. Discuss any risks of use with your doctor.


Side effects may differ from patient to patient. Be prepared for possible side effects and act accordingly if you experience anything. Side effects that persist or worsen require a doctor's attention. See your doctor if you experience persisting or worsening side effects. Common side effects seen with niacinamide are:

  • Diarrhea
  • Nausea
  • Upset Stomach

Many other side effects are possible; always seek medical assistance if you feel it is warranted or if you are troubled or concerned.

Severe Side Effects:

This drug is tolerated well by many users, but in some cases people have experienced severe side effects. Severe side effects require medical attention immediately. A partial list of some of the more commonly seen severe side effects is listed below.

  • Jaundice
  • Swelling of Arms and/or Legs
  • Kidney Problems
  • Easy Bruising and/or Bleeding
  • Nausea and/or Vomiting that Persists
  • Vomit (that appears as coffee grounds)
  • Changes in Urination Flow or Amount
  • Dark Urine
  • Black and/or Tarry Stools

Severe Allergy Warning:

If you experience any signs of a severe allergic reaction, seek emergency medical help at once. Some of the known signs of a severe allergic reaction are listed below. Please note that there could be other signs of severe allergic reaction that are not listed herein, so if you experience anything that feels like it could be a severe allergic reaction or anything that feels severe in any way… seek medical attention at once.

  • Difficulty Breathing
  • Rash
  • Swelling (especially notice the face, throat, and tongue)
  • Extreme Dizziness


Anyone considering the use of this drug in any form should first consult with their primary care doctor, have a complete physical screening, and talk to their doctor about all possible contraindications relevant to their condition orhealth status. Never take or use this drug in any form unless given permission to do so by your primary care doctor.

Niacinamide may be contraindicated for the following conditions:

  • Ulcer from Stomach Acid
  • Liver Problems or Issues
  • Gout
  • Bleeding from Artery
  • Increased Risk of Bleeding (due to a clotting disorder)
  • Severe Constricting Chest Pain
  • Rhabdomyolysis
  • Abnormally Low Blood Pressure
  • Diabetes

There may be many more conditions that could contraindicate the use of niacinamide. Talk to your doctor to be sure niacinamide is safe for you.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA