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Methylprednisolone is a custom-made pharmacy drug classified as a corticosteroid hormone, or glucocorticoid. It is prescribed for the treatment of a variety of conditions due to its effectiveness in suppressing the body's immune system responses to select diseases, which may allow for a dramatic decrease in typically associated symptoms. Methylprednisolone is sometimes used to combat many of the following: certain cancers, lung diseases and/or respiratory problems, immune system disorders, skin and eye conditions/diseases, arthritis, intestinal diseases, lupus or systemic dermatomyositis, blood disorders, kidney problems or diseases, and severe allergic reactions.


Methylprednisolone can be compounded into various forms of delivery at your doctor's request, but is often given orally with milk or food. Your doctor will advise you on usage and provide details on proper dosing amounts. Your doctor may change your dosage during your treatment so be aware of any changes and always follow your doctor's specific directions on dosage and usage. Never discontinue use of this drug without first consulting with your doctor.


You may experience some unwanted side effects during your course of methylprednisolone. Watch for side effects and contact your doctor promptly if you experience any side effect that tends to linger, persist, or seems to be getting worse or changing. For your convenience, a partial list of some of the more typical side effects is provided below. Please note this list is only a partial list and some patients may encounter side effects not listed herein. Regardless of whether the side effect you experience is listed or not, always seek medical treatment if any side effect is troubling, worsening, or continuing.

Partial List of Some Common Side Effects:

  • Vomiting and/or Nausea
  • Dizziness
  • Insomnia
  • Sweating
  • Heartburn
  • Acne
  • Thinning Skin
  • Headaches
  • Change in Appetite
  • Confusion
  • Excitement

Severe Side Effects:

Select patients or users of methylprednisolone may experience severe side effects that warrant immediate medical attention. If you experience anything that feels severe, or any of the known severe side effects listed below, get medical help at once. For your convenience some of the more well known severe side effects are listed below.

Related to Allergic Reaction:

  • Rash
  • Hives
  • Itching
  • Swelling (face, lips, or tongue)

Related to Mood/Mental Health:

  • Anxiety
  • Depression
  • Psychosis
  • Extreme Excitement
  • Change in Personality

Related to the Eye:

  • Vision Changes
  • Eye Pain
  • Bulging Eyes

Related to Diabetes:

  • Increased Thirst
  • Increased Urination

Related to Infection:

  • Sore Throat
  • Fever
  • Coughing
  • Sneezing

Low Potassium Levels:

  • Weakness
  • Irregular Heart Rhythm or Beat

Related to Hormone Changes:

  • Headaches
  • Joint and/or Muscle Pain
  • Low or No Energy
  • No Appetite
  • Nausea
  • Vomiting
  • Fever
  • Skin Irritation
  • Weight Loss
  • Low Blood Pressure
  • Feeling Dizzy or Faint

Other Severe Side Effects:

  • Trouble Urinating
  • Change in Urination Patterns
  • Pain (back, hips, ribs, shoulders, arms, or legs)
  • Swelling (ankles, feet, hands)
  • Wounds (that won't heal)

NOTE: Taking methylprednisolone may dramatically increase your chance of experiencing greater side effects from aspirin, warfarin, and heparin. Ask your doctor for more information if you are taking any of the aforementioned drugs.

NOTE: Taking certain drugs such as phenobarbital, phenytoin, and rifampin may weaken the potency of methylprednisolone. If you are taking any of the aforementioned, be sure to let your doctor know at your initial consultation.

NOTE: Taking troleandomycin, ketoconazole, or cyclosporine may increase your chances of experiencing side effects with methylprednisolone. Talk to your doctor about the risks of side effects if you are taking any of the aforementioned drugs.


There are many diseases, conditions, and situations that contraindicate the use ofmethylprednisolone. Do not take this drug until you have discussed all possible contraindications with your doctor and he or she has decided that there are no contraindications germane to your condition or health status, age, or other.

Do not use methylprednisolone unless you have completed a full medical screening and consultation with your primary care doctor and he or she has decided that this drug is appropriate and safe for your use.

WARNING: While taking methylprednisolone do not take or receive any live vaccines such as any of the following, or any other live vaccines:

  • Varicella Vaccine
  • Nasal Flu Vaccine
  • Rubella Vaccine
  • Measles Vaccine
  • Mumps Vaccine

NOTE: Methylprednisolone may interact with many other medications and drugs (pharmaceutical or street). Do not take or use methylprednisolone until you have informed your doctor of everything you are taking or have recently taken and he or she has decided that there will be no harmful or potentially harmful drug interactions.

WARNING: Tell your doctor if you have a weakened immune system. This drug may not be advisable if your immune system is weakened.

WARNING: Methylprednisolone may retard growth in children. Ask your child's doctor for more information if methylprednisolone is prescribed for your child.

Methylprednisolone is contraindicated for breastfeeding.

Methylprednisolone is possibly contraindicated for pregnancy. Do not take this drug if you are pregnant or planning to become pregnant unless your primary care doctor has cleared you to take it.

WARNING FOR SENIORS: Methylprednisolone may raise the risk of side effects in seniors who have slower working kidney functions. Talk to your doctor about this if you are a senior, or providing care to seniors who are taking this medication.

LONG-TERM USE WARNING: Long-term use of this drug carries an increased risk for many medical problems, conditions, or situations. Talk to your doctor about the risks of long-term usage.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA