Call us
List of Medications


Methotrexate is classified as an antimetabolite, a metabolism blocker. As metabolism is important to cellular production and energy, methotrexate may be effective in the treatment of many diseases in which rampant cellular growth has a deleterious effect. Methotrexate is a powerful drug used in the treatment of various cancers but it also has been utilized in the treatment of other conditions, rheumatoid arthritis and psoriasis to name just a few


Methotrexate is not for daily use. Talk to your doctor about dosage and follow your doctor's directions exactly. Methotrexate is an extremely potent drug and overdosing, even slightly, can be extremely harmful, or fatal. Do not take this drug unless your doctor has deemed it necessary for your treatment and has explained in detail exactly what your dosage should be.


Side effects may occur while taking this powerful drug. If you experience any side effect that is persisting or getting worse, see your doctor. A partial list of some of the more commonly experienced side effects is below. Note this list is only a partial list and it is entirely possible that you may experience other side effects not listed.

  • Headache
  • Drowsiness
  • Dizziness
  • Decrease in Appetite
  • Reddened Eyes
  • Hair Loss
  • Swollen Gums
  • Tender Gums

Severe Side Effects:

It is possible for some patients to experience more severe side effects while using methotrexate. Always watch for side effects and if you experience anything that feels severe, or any of the commonly seen, known severe side effects listed below, get emergency medical treatment immediately.

  • Trouble Moving One Side, or Both Sides, of the Body, or Weakness
  • Confusion
  • Sudden Loss of Vision
  • Blurry Vision
  • Loss of Consciousness
  • Seizures


Never take methotrexate in any form unless you have seen your doctor, consulted with her or him, completed a full medical review, and she or he has deemed the use of this drug to be absolutely necessary for your treatment.

It is extremely important to inform your doctor about any and all other drugs (street or prescription), supplements, herbals, etc. that you are currently taking or have recently taken. Never take methotrexate unless your doctor has prescribed it for you with the full knowledge of the aforementioned.

Methotrexate is contraindicated for the following:

  • Pregnancy
  • Breastfeeding

Methotrexate may be contraindicated for any of the conditions listed below. Check with your doctor about all possible contraindications, especially if you have any of these conditions listed below.

  • Defective Growth of Bone Marrow
  • Severely Diminished Platelets
  • Diminished White Blood Cells
  • Habit of Excessive Alcohol Drinking
  • Interstitial Pneumonitis
  • Escape of Fluid into Lungs
  • Lung Fibrosis
  • Severe Infection
  • Severe Loss of Body Water
  • Defective Immune System (or conditions related to or caused by)
  • Diminished Function of Bone Marrow
  • Low Blood Counts (due to bone marrow failure)
  • Canker Sore or Sores
  • Diarrhea
  • Severe Anemia
  • Ascites
  • Ulcer from Stomach Acid
  • Ulcerated Colon
  • Hardening of Liver
  • Excess Liver Fibrous Tissue
  • Abnormal Liver Function Tests
  • Severe Liver Disease
  • Kidney Disease (with reduction in kidney function)
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA