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Medroxyprogesterone is a custom pharmacy drug that is classified as a progestin. Progestins are synthetic, or natural, steroid hormones. Medroxyprogesterone enables the uterus to produce select hormones that help to regulate or treat various functions within the female body. Medroxyprogesterone is often prescribed to treat erratic vaginal bleeding, to regulate menstrual cycles that have become abnormal, to prevent excessive or irregular growth of the uterus, and to reduce the chance of developing endometrial hyperplasia (which in some cases can lead to an increased risk of developing cancer) in women who take estrogen.


Medroxyprogesterone may be ordered in various forms by your physician, from tablets to injection. Consult with your physician about your options for method of delivery then see your compounding pharmacist to fill your prescription. Your compounding pharmacist will be happy to provide you with more information and answer any questions you may have about medroxyprogesterone. If you are given the tablet form of medroxyprogesterone, take it orally at the same time on your scheduled dosing days as per your physician's directions. Follow your physician's directions on dosage and usage precisely. Never take more than your physician-directed dosage, and never stop taking this drug without first consulting with your physician.


You may encounter some unwanted side effects while taking medroxyprogesterone. While some side effects may be mild and go away on their own in a few days or weeks, other side effects may prove to be more nagging, may worsen, or linger. If you experience any side effect that tends to linger or is worsening, contact your physician right away. Common side effects that may be experienced by patients using medroxyprogesterone are:

  • Breast Tenderness
  • Breast Discharge
  • Stomach Discomfort
  • Nausea
  • Weight Gain (or loss)
  • Vision Changes
  • Feeling Anxious or Nervous
  • Dizziness
  • Headache
  • Depression
  • Spotting
  • Changes in Menstrual Periods
  • Vaginal Itching
  • Vaginal Discharge
  • Swelling (veins)
  • Insomnia
  • Itching and/or Rash
  • Acne
  • Hair Growth
  • Hair Loss
  • Premenstrual Symptoms (Retention of Fluids, Bloating, Changes in Mood)

Severe Side Effects:

Unfortunately some patients may experience side effects that are severe and require immediate medical attention. You may experience no side effects at all, but if you do experience anything that feels severe, or anything listed below, get medical treatment immediately.

  • Symptoms of Depression
  • Jaundice
  • Vaginal Bleeding (if you are postmenopausal)
  • Swelling (hands, ankles, feet)
  • Lightheadedness
  • Breast Lump or Lumps
  • Signs of Stroke (Ask your physician for more information.)
  • Signs of Blood Clot in Lung (Ask your physician for more information.)
  • Signs of Blood Clot in Leg (Ask your physician for more information.)
  • Heart Attack Symptoms
  • Slowed or Difficult Speech

It is possible that any patient taking this drug could experience a side effect that is unique to them, or to a smaller group of people, so it is important to remember that you know your body better than anyone else thus if you experience anything at all that feels concerning or troubling or severe, get medical attention at once.

Severe Allergic Reaction:

If you experience anything that feels like an allergic reaction it is important to seek emergency medical care immediately. Allergic reactions can be extremely dangerous and always require prompt medical attention. A partial list of some of the more onerous and obvious signs of allergic reaction is provided below for your convenience.

  • Hives
  • Difficulty Breathing
  • Swelling of the Tongue, Face, Throat, or Lips


There may be many contraindications for the use of medroxyprogesterone. Talk to your doctor about possible contraindications that may apply to you.

It is important for your physician to know your medical history and be cognizant of any medications that you are currently using. Do not use medroxyprogesterone without first consulting with your primary care physician, undergoing a full medical screening with labs, and discussing your current health status, the risks versus benefits of using medroxyprogesterone, and your options in general.

NOTE: While using medroxyprogesterone you should do a monthly check for lumps in your breasts and visit your physician for regular physical exams.

Medroxyprogesterone may be contraindicated for breastfeeding in some cases. Do not use medroxyprogesterone while breastfeeding unless your physician has cleared you for its use.

Medroxyprogesterone is contraindicated for the following conditions:

  • Unusual Genital Bleeding
  • History of Breast Cancer
  • Hormone Related Cancers
  • Liver Impairment
  • Liver Disease
  • Pregnancy
  • Suspected Pregnancy
  • Active Arterial Thromboembolic (or history of)
  • Active DVT or PE (or history of)
  • Liver Disease
  • Liver Impairment
  • Pregnancy
  • Suspected Pregnancy
  • Estrogen or Progesterone Dependent Neoplasia
  • Known Anaphylactic Reaction to Medroxyprogesterone
  • History of Blood Clots

It is important to inform your physician about your medical conditions so they can ascertain whether medroxyprogesterone is safe for your use. Consult with her or him if you have any medical issues whatsoever, and especially if you have, or have had, any of the following:

  • Epilepsy
  • Asthma
  • Pelvic Pain
  • Migraine Headaches
  • Severe Headaches
  • Low Calcium Levels in Blood
  • Heart Disease
  • Congestive Heart Failure
  • Recent Stroke
  • Heart Attack
  • High Blood Pressure
  • Thyroid Disorder
  • Recent Miscarriage
  • Recent Abortion
  • Kidney Disease
  • Kidney Impairment
  • Diabetes
  • Lupus
  • High Cholesterol
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA