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Leflunomide is a custom pharmacy drug that is primarily used in the treatment of rheumatoid arthritis, a condition in which the body attacks its own healthy cells. Leflunomide decreases enzymatic reactions necessary for the body to produce DNA and RNA, which in turn ceases cell replication and protects the body from itself. Leflunomide works at the source of the inflammation that causes the painful, irritating symptoms of rheumatoid arthritis. By working directly at the source of the inflammation, leflunomide can often lessen or end painful symptoms, decrease arthritic deformities, as well as halt the destruction of joints.


Leflunomide is typically given by mouth though your compounding pharmacist may be able to provide any number of other delivery forms if your doctor requests it. Leflunomide oral can be taken with or without food. Follow your doctor's directions for usage and dosage. Your doctor may prescribe a higher dose for the first three days only, if so, be sure to remember to decrease your dose as per doctor's directions.


You may experience side effects while using leflunomide. Contact your doctor right away and get treatment if any side effects worsen or persist. Common side effects seen with leflunomide are:

  • Diarrhea
  • Dizziness
  • Nausea

Severe Side Effects:

If you experience severe side effects seek medical treatment immediately. Some possible severe side effects are as follows:

  • Numbness (hands and/or feet)
  • Tingling (hands and/or feet)
  • Chest Pain
  • Pounding Heartbeat
  • Muscle Cramps
  • Mood Swings
  • Hair Loss
  • Unusual Lumps
  • Tiredness
  • Increase in Thirst
  • Cough
  • Vision Changes
  • Increase in Urination
  • Noticeable Ease of Bruising or Bleeding

Serious Allergic Reaction:

Severe allergic reactions are always serious. Seek medical treatment at once if you experience any signs of a severe allergic reaction. A partial list of possible signs of a severe allergic reaction is provided below.

  • Swelling (pay close attention to the tongue and throat, as well as the face)
  • Difficulty Breathing
  • Rash
  • Itching
  • Severe Dizziness

WARNING: If you experience any rash, seek medical attention right away.

NOTE: Leflunomide may reduce your body's ability to combat infections and also increase blood pressure. Talk to your doctor about these possible risks.


See your doctor for a full medical review before beginning use of leflunomide to decide if this drug is safe for your use.

Leflunomide may be contraindicated for many and various conditions, diseases, and situations; ask your doctor to discuss all possible contraindications before deciding to begin taking this drug.

Leflunomide is contraindicated for anyone with liver problems or abnormal liver test results.

Leflunomide is contraindicated for pregnancy and breastfeeding. Do not take this drug if you are pregnant, planning a pregnancy, breastfeeding or planning to begin.

WARNING: Leflunomide may cause fatal liver failure. Talk to your doctor about the risks versus the benefits of using this drug.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA