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L-glutamine is an amino acid that is organically produced within the human body. It has a vast array of uses in modern medicine as well as the fitness industry. Within the body, l-glutamine is created in the muscles and then passed along to internal organs via the blood. Surgery, as well as an injury that is traumatic, requires nitrogen to help repair the damage and l-glutamine is the producer of a large percentage of this necessary nitrogen. Physicians prescribe l-glutamine to allay negative side effects from various medical treatments. L-glutamine may be prescribed to combat side effects of different cancer treatments, bowel surgeries, trauma, and infections. It is used by some for depression, anxiety, ulcerative colitis, ADHD, sickle cell anemia, digestive system disorders and more.

In the world of health and fitness, l-glutamine is a celebrated supplement. Fitness aficionados and body builders alike praise l-glutamine for its potential to improve protein metabolism and slow the breakdown of muscle. L-glutamine may help to take down body fat without losing muscle, which is why this amino acid is popular in strength training and fitness. Additionally, l-glutamine may possibly increase immunity in some users and is known to be a solid base nutrient for the intestines, which provides for better intestinal health.


L-glutamine comes in various forms, all of which your compounding pharmacist can provide. Depending on your goals or medical condition, your doctor will help you decide what form is best for you. L-glutamine is often given as a liquid, tablet, intravenous solution, capsule, or powder (as is often the preferred choice of bodybuilders). Follow usage and dosage instructions closely and always follow your doctor's recommendations precisely.


L-glutamine is tolerated well by many users, but as each person's particular body chemistry is unique there is no way to know if any one person will be immune to potentially irritating or dangerous side effects. Talk with your doctor about your options and about the risks versus benefits of using l-glutamine. If you experience any side effects that are growing in intensity or persisting, see your doctor right away. Some side effects that could possibly occur are listed below.

  • Nausea or Vomiting
  • Stomach Pain
  • Gas
  • Runny Nose
  • Increased Sweating
  • Swelling (hands or feet)
  • Muscle Pain
  • Back Pain
  • Joint Pain
  • Feeling Exhausted or Tired
  • Headaches
  • Dizziness
  • Skin Rash (mild)
  • Itching
  • Dry Mouth

Severe Side Effects:

L-glutamine may produce severe side effects in some patients or users. Pay attention to any changes you experience and if you feel that you are having a severe side effect, seek medical treatment right away. For your convenience, a partial list of some of the known severe side effects is below.

  • Chest Pain
  • Hearing Problems
  • Signs of Infection (chills or fever, sore throat, symptoms resembling the flu, etc.)

Severe Allergic Reaction:

All allergic reactions are serious. Seek emergency medical treatment immediately if you experience any of the following, or anything that feels severe:

  • Trouble Breathing
  • Hives
  • Swelling (face, lips, tongue, throat)


As with all drugs and supplements, anyone considering the use of l-glutamine should only begin use after a full health screening and consultation with his or her primary care doctor.

L-glutamine may be contraindicated for some conditions or diseases, or due to drug interactions. Have a frank discussion with your doctor about all of your options and discuss any possible contraindications that may be relevant to you, your condition, or age.

There is insufficient data as to the possible effects of l-glutamine in regard to pregnancy or breast milk. Do not take l-glutamine if you are pregnant or breastfeeding or about to become pregnant or begin breastfeeding.

L-glutamine could worsen liver problems. Talk to your doctor.

L-glutamine could exacerbate cirrhosis. Do not take l-glutamine if this applies to you.

If you suffer from mania, do not use l-glutamine.

If you are prone to seizures, do not use l-glutamine as its use may dramatically increase the chances of having a seizure.

If you are taking a seizure medication currently or have taken one in the recent past, do not use l-glutamine.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA