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Indomethacin is classified within the family of medicines known as nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin works to combat inflammation, fever, and pain by blocking enzymes and thus decreasing the body's production of certain chemicals—prostaglandins—that originate the symptoms associated with inflammation. Indomethacin is often prescribed for various types of arthritis, bursitis, and tendinitis.


Indomethacin comes is various forms of delivery from suspensions to tablets, capsules, extended release capsules, suppositories and injections. Ask your doctor what method of delivery is best for you. As each method of delivery has specific dosing directions unique to a patient's condition, your doctor will confer with you on a dosage and usage plan that meets your needs. After being prescribed indomethacin, consult with your compounding pharmacist and he or she will work with you to provide indomethacin in the form that your doctor mandates.


Some users may experience no side effects; still others may experience one or perhaps more side effects. Common side effects seen with indomethacin are:

  • Ringing in Ears
  • Nausea and/or Vomiting
  • Constipation or Diarrhea
  • Upset Stomach
  • Dizziness
  • Drowsiness
  • Feeling Tired
  • Headaches

Monitor your condition. Get medical treatment if you feel it is needed, and certainly if you experience any side effects that are increasing, worsening, or persisting.

Severe Side Effects:

Some side effects may be severe and require medical attention. If you experience anything severe, or that feels severe, or any of the side effects listed below, see your doctor right away.

  • Quick Weight Gain
  • Shortness of Breath
  • Changes in Vision
  • Severe Skin Reactions (ask your doctor for more information)
  • Swelling
  • Anemia
  • Skin Rash (even a mild rash warrants attention)
  • Stomach Bleeding
  • Vomit (that looks like coffee grounds)
  • Bloody and/or Tarry Stools
  • Coughing up Blood
  • Kidney Problems (ask your doctor for more information)
  • Liver Problems (ask your doctor for more information)


If you are considering indomethacin as a possible treatment for your condition, see your primary care doctor and have a full consultation, physical, and medication overview before beginning use of this drug. Ask your doctor about possible contraindications.

Do not use indomethacin if you are pregnant or planning a pregnancy, breastfeeding or about to begin breastfeeding.

Indomethacin can increase the risk of potentially fatal heart attacks and/or strokes. All patients, especially those with a history of any heart conditions, must consult with their primary care doctor about the benefits versus the risks of taking indomethacin.

Never use indomethacin before or after any type of surgical procedure related to the heart or its function.

Indomethacin can sometimes cause internal bleeding which could potentially be fatal. It is important to discuss the risks with your doctor before beginning use of indomethacin, especially if you are elderly.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA