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Idebenone is a custom-made drug classified within the family of drugs known as quinones. Similar to the widely used antioxidant coenzyme Q-10, idebenone has shown promise of holding potentially strong antioxidant properties as well and is believed to have protective power against cellular oxidative damage in the body. Idebenone is prescribed for many diseases and conditions such as liver disease, heart disease, Alzheimer's disease, Leber's disease (a condition of the eye), Friedreich's ataxia, as well as several muscle and nerve disorders.

Idebenone is a popular anti-aging ingredient in many facial creams designed to drastically reduce wrinkles and damage from the sun. Certain serums that utilize the properties of idebenone are actually activated by body heat making them potentially ideal, in some users, for use when exposed to heat and sunlight.


Idebenone is often prescribed as an oral medication for disorder and disease treatment but your compounding pharmacist can work with your doctor to craft the drug into other forms of delivery such as suspensions, etc. if your doctor requests an alternative. Consult with your compounding pharmacist for more information. Follow your doctor's specific instructions on dosing and never take more than prescribed. Idebenone is a very active medication and your doctor will prescribe a dosage that is adequate for treatment of your condition.

As a topical anti-aging agent, idebenone is often part of compounds delivered as creams and serums that help to prevent some of the free radical damage we are exposed to daily in our environment. Idebenone compounds are best used along with a robust sun block cream or lotion.


In most cases, patients seem to tolerate the use of idebenone very well and experience few if any side effects. However, every person is unique and what may be an easy path for some may prove to be more difficult for others based on their individual body chemistry. Watch for side effects and if anything develops that is concerning, talk to your doctor right away. As with any drug, some patients may experience mild side effects upon beginning use or during the course of use. With idebenone, the more likely side effects to occur would be:

  • Stomach Upset
  • Headaches
  • Extreme Alertness or Clarity (thus avoiding bedtime dosing is probably best)
  • Abdominal Pain
  • Dyspepsia
  • Nausea
  • Diarrhea

Possible Side Effects As a Topical:

  • Allergic Reaction (seek medical treatment immediately)
  • Rash
  • Contact Dermatitis


In general, anyone planning to begin use of any new medication should not begin until having a full medical screening and consultation with their primary care doctor that includes a comprehensive discussion of all medications they are currently taking or have taken in the relatively recent past.

Do not use idebenone if you are pregnant, planning a pregnancy, breastfeeding or about to begin breastfeeding.

Idebenone is contraindicated for the following conditions:

  • Hepatic Impairment
  • Renal Impairment
  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA