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Hyaluronidase is a genetically created protein, an enzyme that accelerates the hydrolysis of hyaluronic acid, which is the foundation material of connective tissues within the body. In humans, hyaluronic acid can be found in testicles. In animals, it is found in the venom of spiders and snakes, and in leeches. One of hyaluronic acid's primary uses is to benefit subcutaneous injections by aiding in the absorption and diffusion once injected. Hyaluronic acid can make injections more efficient, less painful, and aid in the quick release of the solution that is injected so it can 'go to work' faster. Hyaluronic acid can be a good alternative strategy for increasing injection efficiency when a patient cannot tolerate intravenous release of a specific drug due to their condition or health status, or when there are other medical reasons to avoid an intravenous route. Hyaluronic acid is also used in combination with other fluids to decrease dehydration in some patients.


Hyaluronidase is an injectable and comes in solution form and powder for solution form. Ask your doctor for more information. If your doctor orders the use of hyaluronidase it may be given as an injection at your doctor's office. Consult with your compounding pharmacist if you have specific questions about any drug or medication that you are prescribed by your doctor. Follow your doctor's specific directions for the use of hyaluronidase.


When taking any new drug your body may require some time to adjust to it therefore some side effects may be experienced. Additionally, some patients simply may not be able to tolerate a drug and thus they will also experience side effects. Whatever the case, note any side effects that you experience and if they are worsening or persisting, contact your doctor. For your convenience partial lists of possible side effects are provided below, but it is important to note that you could possibly experience other side effects that are not listed. Always seek emergency medical treatment immediately if you experience anything, side effects or otherwise, that feels severe or dangerous.

More Commonly Seen Side Effects:

  • Blistering and/or Burning
  • Bleeding
  • Infection
  • Inflammation
  • Numbness
  • Discoloration of Skin
  • Feeling of Pressure
  • Coldness
  • Swelling and/or Tenderness
  • Hives and/or Itching
  • Warmth at Site of Injection
  • Lumps
  • Rash
  • Stinging
  • Redness
  • Ulceration
  • Scarring
  • Soreness
  • Pain and/or Discomfort
  • Tingling

Rare, but Possible Side Effects:

Contact your doctor, or get medical treatment, immediately if you experience any of the following side effects.

  • Swelling around Eyes, Face, Lips, or the Tongue
  • Swelling of the Face, Eyelids, Lips, Tongue, and Throat
  • Swelling of the Hands, Legs, and Feet
  • Puffiness and/or Swelling in the Eyelids
  • Swelling of the Sex Organs
  • Unusual Tiredness
  • Unexplained or Unusual Weakness
  • Dizziness
  • Tightness in Chest
  • Rapid Heartbeat
  • Cough
  • Skin Redness and/or Rash
  • Hives and/or Welts
  • Itching
  • Difficulty Swallowing

Signs of Possible Overdose:

If you experience any of the following you may be in the midst of an overdose; if you do, get medical treatment immediately:

  • Nausea and/or Vomiting
  • Chills
  • Swelling
  • Unusual Tiredness and/or Weakness
  • Unusually Warm Skin
  • Confusion
  • Blurred Vision
  • Dizziness and/or Faintness
  • Sweating
  • Lightheadedness When Rising Suddenly
  • Irregular Heartbeat and/or Pulse
  • Fast Heartbeat and/or Pulse
  • Pounding Heartbeat and/or Pulse
  • Skin Redness


As you can see from the above lists of side effects and signs of overdose, there is some overlap of warning signs or symptoms, and side effects. Only you can decide if your side effect or symptom warrants a call to your doctor or immediate emergency medical treatment. If you experience anything whatsoever that feels severe, is worsening rapidly, or could possibly be an allergic reaction (ask your doctor about signs of allergic reaction) or overdose symptom, do not take a chance, get emergency medical treatment immediately.


All patients are advised to have a full medical screening with their primary care doctor to assess their health status before using hyaluronidase.

Pregnancy / Breastfeeding:

Women who are pregnant, or planning a pregnancy, breastfeeding or planning to breastfeed should not use hyaluronidase unless they have had a comprehensive medical evaluation and consultation with their primary care doctor and he or she has deemed it absolutely necessary for their treatment.

Hyaluronidase is contraindicated for anyone with a hypersensitivity to hyaluronidase or any of its ingredients. Ask your doctor for more information on this.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA