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Guafenesin is an expectorant, a custom-made pharmacy drug widely prescribed by physicians for treatment of congestion due to allergies, common colds, bronchitis, and infection. Guafenesin works by loosening congestion and breaking it up so it can be coughed through the mouth and thus provide for better breathing.


Guafenesin is often given as a liquid medication but may also be administered via extended-release and controlled-release tablets and capsules. Never break, split, or crush capsules or tablets as this may cause a potential overdose. Drink plenty of water while taking this drug. If you are having issues with upset stomach, take with food. Do not give guafenesin to any child under the age of 6 years unless instructed to do so by your child's pediatrician or primary care physician. Some extended-release type capsules and tablets may be contraindicated for use by anyone under the age of 12 years, so ask your physician before administering to anyone 12 years or younger.


It is possible to encounter some side effects while using guafenesin. If you think you are experiencing any side effects that are lingering or growing in intensity, contact your physician right away. Common side effects seen with guafenesin are:

  • Nausea and/or Vomiting
  • Drowsiness / Tiredness
  • Diarrhea
  • Dizziness
  • Rash and/or Hives
  • Stomach Pain
  • Headaches
  • Decreased Uric Acid Level


If you experience any signs of a potentially severe allergic reaction, seek emergency medical treatment immediately. Ask your physician about symptoms of severe allergic reaction. Allergic reactions are serious and always require medical treatment.


Check with your primary care physician for complete information on all possible contraindications.

Guafenesin is contraindicated for anyone with a hypersensitivity to guafenesin or any active or inert ingredients.

Guafenesin is contraindicated for anyone with nephrolithiasis (the process of forming kidney stones).

Guafenesin is probably contraindicated for anyone under the age of 6 years old. Ask your physician.

There may be other medical conditions and drug interactions that could create contraindications regarding the use of guafenesin. Consult with your physician and ask him or her to provide you with information regarding possible contraindications specific to you.

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