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Estrone is a steroid and one of the three primary endogenous estrogens alongside estradiol and estriol. After menopause, a lowered level of estrogen may make the body more susceptible to diseases such as Alzheimer's, Tourette's, and Parkinson's, and keeping estrogen levels regulated may help combat these potential problems. Estrone is sometimes prescribed for treatment of the following:

  • Hypogonadism
  • Primary Ovarian Insufficiency
  • Hot Flashes
  • Menorrhagia
  • Premature Menopause
  • Prostatic Neoplasms

Additionally, estrone is sometimes given to prevent premature osteoporosis.


Estrone typically is administered as an injectable suspension, injectable solution, or vaginal suppository. If you are prescribed estrone, your physician will assess your health, age, condition, and desired outcome and prepare a plan. Follow your physician's directions on usage. Your compounding pharmacist will work with your physician to prepare estrone for use in your treatment.


Side effects may be experienced while using estrone. Pay close attention to your body during your course and watch for any of the following:

  • Depression
  • Bloating or Nausea
  • Vomiting
  • Chorea
  • Cramps
  • Epilepsy
  • Abdominal Pain
  • Changes in Vaginal Discharge
  • Spotting
  • Tender Breasts
  • Headache
  • Gallbladder Disorder
  • Vaginal Moniliasis
  • Dizziness
  • Endometrial Hyperplasia
  • Rash
  • Hypocalcaemia
  • Fibrocystic Breast Disease
  • Hirsutism
  • Jaundice
  • ​Pancreatitis
  • Chloasma
  • Pruritus
  • Irritability
  • Metrorrhagia
  • Myocardial Infarction
  • Asthma Increase or Worsening
  • Endometrial Cancer
  • Dementia
  • Increase of Blood Pressure
  • Retinal Vascular Thrombosis
  • Ovarian Cancer
  • Abdominal Bloating
  • Pulmonary Embolism
  • Urticaria
  • Cerebrovascular Accident

The list of possible side effects and symptoms above is only a partial list. Speak with your physician for a more in-depth overview of the risks of using estrone. Always get medical treatment immediately if any side effect is severe, troubling, worsening, or persisting.


Never take estrone if you are pregnant or planning a pregnancy. Estrone may cause birth problems or harm a fetus.

Talk to your physician about all the possible contraindications. Do not take this drug without a physician's approval.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA