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Estriol is an endogenous estrogen, an important estrogen produced by the placenta during pregnancy. It is a steroid that is used in bioidentical hormone replacement therapy. It may possibly improve heart health and bone density, and may be useful in the treatment of multiple sclerosis, as well as some postmenopausal conditions such as vaginal dryness and hot flashes. Additionally some studies have shown it to be effective as part of a temporary anti-aging regimen.


Estriol can be compounded by your pharmacist into many different forms of delivery from tablets to cream and more. Discuss your options with your primary care physician and he or she will advise you on form, dosage or usage instructions. If you have further questions after being prescribed estriol ask your physician or contact your compounding pharmacist.


Side effects are possible. Until you begin taking estriol there is no way to know which side effects, if any, you will experience. Common side effects seen with estriol are:

  • Depression
  • Feeling Sick
  • Bloating
  • Painful Urination
  • Excessive Urination
  • Gall Bladder Problems
  • Dark Patches on Skin
  • Red Marks on Skin
  • Skin Rash
  • Sun Allergy
  • Red Painful Swelling or Bruising
  • Memory Loss
  • Abdominal Pain
  • Leg Cramping
  • Premenstrual Tension
  • Vaginal Irritation or Itching
  • Increase of Vaginal Discharge
  • Fast Heartbeat
  • Irregular Heartbeat
  • Abnormal Bleeding of Vagina
  • Spotting
  • Painful Breasts
  • Tender Breasts
  • Headache

Other side effects could occur. Seek medical assistance if you feel it is warranted, or if any side effects are persisting or worsening.

Severe Side Effects:

Get medical help immediately if you experience any of the following severe side effects or any other side effect that feels severe or concerning:

  • Swelling of Throat or Face
  • Difficulty Swallowing
  • Trouble Breathing
  • Blistering of Skin
  • Dimpling of Skin on Breast
  • Change in Nipple
  • Lumps in Breast
  • Chest Pain that Spreads to Arm or to Neck
  • Jaundice
  • Swelling in Legs
  • Blood Pressure Increase
  • Unexplained Migraines


Do not take estriol if you are pregnant or breastfeeding, or plan to become pregnant or begin breastfeeding.

There are many medical conditions of which estriol is, or may be, contraindicated. All patients considering the use of estriol should meet with their primary care physician and discuss their options after completing a full medical review and drug interaction review.

Consult with your primary care physician for a full list of possible contraindications before begging use of estriol.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA