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Diphenhydramine is an antihistamine; it works within the body to combat a chemical known as histamine that can cause irritating symptoms such as runny nose, watery eyes, itching, and sneezing. Lauded mostly as a cold and allergy medication, this custom-made drug is also prescribed as a treatment for Parkinson‘s disease, motion sickness, and sometimes as a sleep inducer.


Diphenhydramine can be administered in many forms from tablets to strips, powders to capsules, and more, each with its own specific directions for dosage and usage; consult with your physician about which form is right for you. Consult with your compounding pharmacist after being prescribed diphenhydramine and he or she will compound the drug into a form of delivery that will work best for you and your condition.


Side effects could possibly occur with the use of diphenhydramine. Common side effects seen with this drug are as follows:

  • Chest Congestion
  • Dizziness
  • Headache
  • Nausea
  • Vomiting
  • Loss Of Appetite
  • Constipation
  • Dry Mouth,
  • Dry Nose
  • Dry Throat
  • Drowsiness / Tiredness
  • Muscle Weakness
  • Nervousness
  • Excitement

If any of the above or any other side effects are experienced, seek medical assistance if you feel it is warranted or if any side effects are growing in intensity or lingering.

Serious Side Effects:
NOTE: If you experience vision problems or painful/difficult urination, get medical help immediately as these could be potentially serious side effects.


Although antihistamines are commonly used drugs, still they can interact negatively with many other drugs, be contraindicated for many patients with various diseases, conditions, allergies, susceptibilities, and current or past medical histories; thus, it is important for all patients, or guardians/parents of patients, considering the use of diphenhydramine to consult with their physician before beginning use.

Remember to always disclose all medications and drugs (street or pharmaceutical) as well as any supplements to your physician to be sure that he or she is aware of any possible drug interactions that could occur if you begin taking diphenhydramine.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA