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Cyclophosphamide is classified as an antineoplastic; it is a custom pharmacy drug designed to retard or stop the growth or advancement of cancer cells. Cyclophosphamide is used predominantly in the treatment of many and various cancers but it is also sometimes prescribed to treat kidney issues in children.


Cyclophosphamide is most often given to patients as an injectable medication, by their doctor or healthcare provider; however, doctors may prescribe cyclophosphamide for at home use. If you are given a prescription for this drug and planning to administer cyclophosphamide in your home, be sure to receive a full and detailed training and usage demonstration for proper administration of the drug. Drink additional amounts of fluids and urinate often to empty out your bladder while taking cyclophosphamide.


Side effects can differ from individual to individual while taking this drug. Some of the more common side effects seen with cyclophosphamide are:

  • Changes in Skin Color
  • Changes in the Color of Fingernails or Toenails
  • Growth Changes in Fingernails or Toenails
  • Nausea and/or Vomiting
  • Diarrhea
  • Hair Loss
  • Loss of Appetite
  • Sores on Tongue
  • Sores in Mouth
  • Weight Loss
  • Abdominal Pain

If any of the above side effects are experienced and are increasing in intensity and/or lingering, contact your doctor. Also contact your doctor if you experience other side effects that are troubling to you.

Side effects can be quite serious in some patients. If you experience any of these serious side effects, seek medical treatment immediately:

  • Sore Throat, Chills, and/or Fever
  • Signs of an Infection
  • Rash or Hives
  • Chest Pain
  • Difficulty with Breathing
  • Trouble Swallowing
  • Slowed Wound Healing
  • Atypical Bruising
  • Atypical Bleeding
  • Black Stools
  • Tarry Stools
  • Yellowing in the Eyes
  • Yellow Skin
  • Painful Urination
  • Red Urine Color
  • Itching
  • Swelling in Legs or Ankles
  • Cough
  • Swelling of the Feet
  • Shortness of Breath


Cyclophosphamide is strictly contraindicated for pregnancy and breastfeeding. Do not take this drug if you are pregnant or breastfeeding, or planning to. Use extra caution and care to be sure to avoid becoming pregnant while using this drug, as cyclophosphamide is known to harm a fetus.

There are many other drugs and medical conditions of which the use of cyclophosphamide may be contraindicated or not advisable. Check with your doctor before beginning use of cyclophosphamide.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA