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Creatine is a naturally occurring chemical that can be found in the human body and in foods such as seafood and red meat. Creatine can also be a laboratory drug and is often manufactured as a supplement designed to improve overall performance in physical exercise and/or to help build muscle mass, or possibly, in some patients, improve the look and feel of aging skin. While it is often thought that creatine is an athlete's drug predominantly, it may be helpful for senior adults whose muscle systems have trouble building up on their own, for them it can possibly provide a boost to help achieve a healthier muscle mass.

In addition to the commonly known uses of creatine that are widely reported, creatine is also given orally for many diseases and medical conditions that are caused by a creatine deficiency. A partial list of these is provided below; ask your doctor if creatine may be helpful in your treatment if you suffer from any of the following:

  • Chronic Obstructive Pulmonary Disease (COPD)
  • Congestive Heart Failure
  • Depression
  • Muscle Breakdown (in Spine)
  • Head Trauma
  • Diabetes
  • Fibromyalgia
  • Diseases Of The Muscles And Nerves
  • Multiple Sclerosis
  • Parkinson's Disease
  • Breathing Problems In Infants
  • Gyrate Atrophy
  • Muscle Atrophy or Muscle Cramps
  • Rett Syndrome
  • Schizophrenia

Creatine may be prescribed as part of a treatment plan for ALS, Rheumatoid Arthritis, Muscular Dystrophy, Osteoarthritis, Amyotrophic Lateral Sclerosis, McArdle's Disease and more.

How to Use Creatine

Creatine can be prepared by your compounding pharmacist in many forms from topical ointments and creams, to oral tablets and powders, to intravenous solutions. Some forms are for general health while others are primarily used during surgeries in a hospital setting. Anyone considering the use of creatine in any from should first consult with their physician before beginning use of this drug. Creatine may cause dehydration; if using creatine, always drink plenty of water.

Possible Side Effects

Side effects may be possible with the use of creatine. Observe your body while taking creatine and if you experience any of the following, or other side effects that are concerning to you, contact your physician:

  • Gaining Weight
  • Diarrhea
  • Rash
  • Upset Stomach
  • Anxiety
  • Breathing Trouble
  • Difficulty Breathing
  • Headache
  • Kidney Problems or Issues
  • Fatigue
  • Fever
  • Nausea and/or Vomiting

If you experience any side effects that are increasing or lingering, seek medical treatment right away.


Do not take creatine if you have liver disease, kidney disease, or diabetes.

Do not take creatine if you are breastfeeding, or about to begin, or pregnant or about to become pregnant.

Do not take creatine if you are under the age of 18 years.

Creatine may impact blood sugar levels. Discuss this with your physician before beginning use of creatine.

All patients considering the use of creatine should first consult with their physician before beginning use of the drug, as it is extremely important for them to know your complete medical history and be aware of any medications that you are currently taking. Creatine may negatively interact with many drugs, supplements, medications, etc. so inform your physician of everything that you are taking, from simple supplements to medications and pharmacy drugs, to street drugs, or other.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA