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Clomipramine is a tricyclic antidepressant, a custom-made drug that is prescribed for patients with Obsessive Compulsive Disorder, often referred to as simply OCD. Clomipramine works by increasing the levels of serotonin in the brain, which may help to achieve mental balance.

How to Use Clomipramine

Clomipramine is often given in capsule form up to 3 times throughout the day. It should be taken with food to help decrease the possibility of an upset stomach. If a dose is missed, take the dose as soon as you remember that you missed it unless it is near the time for your next dose. Never take a double dose. Take only as prescribed by your doctor. Patients may not see any results for 3 weeks and this is normal as tricyclic antidepressants sometimes take a while to build up in the body before a patient begins to feel the drug's effect.

Possible Side Effects

It is impossible to predict if patients will experience any side effects until their course is underway so watch for signs of side effects and contact your doctor if any of the following side effects seem to be hanging or worsening:

  • Decreased Sexual Ability
  • Drowsiness
  • Dry Mouth
  • Nausea
  • Change in Appetite or Weight
  • Vomiting
  • Nervousness
  • Decreased Memory or Concentration
  • Diarrhea
  • Constipation
  • Headache
  • Stuffy Nose

Severe Side Effects:

Call your doctor and seek immediate medical help if you experience any of the following severe side effects:

  • Uncontrollable Shaking of the Body
  • Seizures
  • Loss of Bladder Control
  • Difficulty Urinating
  • Fast Heartbeat
  • Irregular Heartbeat
  • Pounding Heartbeat
  • Difficulty Breathing
  • Hallucinations
  • Believing Things That Are Not True
  • Signs of Infection
  • Shakiness
  • Fast Breathing
  • Muscle Stiffness (severe)
  • Unusual Tiredness
  • Weakness
  • Sore Throat or Fever


Clomipramine may interact with myriad other drugs and may be contraindicated for many patients with various conditions or diseases; therefore, all patients considering the use of clomipramine must consult with their doctor before beginning use of this medication.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA