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Ceftriaxone is classified in the family of cephalosporin antibiotics; it works to kill bacteria. Ceftriaxone is prescribed by doctors for the treatment of many medical issues and conditions, the most common being pneumonia, lung infections, pelvic inflammatory disease, gonorrhea, meningitis, abdominal infections, urinary tract infections, infections of the blood, skin, bone, and joint. Ceftriaxone is also commonly given to surgical patients before surgery to prevent post-surgical infections. Additionally, ceftriaxone has been used in the treatment of many other medical conditions. Talk to your doctor about your options.

How to Use Ceftriaxone

Ceftriaxone is an injectable medication. Healthcare providers will give patients injections within a healthcare facility. Ceftriaxone can be given intravenously or intramuscularly. If a physician prescribes ceftriaxone for at home use it is important that you understand how to use it properly. Your healthcare provider should provide you with specific training and instructions on how to administer ceftriaxone in your home. Do not skip doses. Use as directed.

Possible Side Effects

Side effects are possible. If you are experiencing any of the following common side effects and they are getting worse or lingering contact your physician:

  • Diarrhea
  • Pain, Tenderness, Hardness, or Warmth (at or near the injection site)
  • Pale Skin
  • Weakness
  • Shortness of Breath when Exercising

Other side effects have been experienced, monitor your condition closely and always seek medical help if you feel it is warranted.

Serious Side Effects

Seek emergency medical assistance immediately if you experience any of the following serious side effects:

  • Bloody Stool
  • Watery Stool
  • Stomach Cramping
  • Fever
  • Rash
  • Stomach feeling Tender, Pain, or Bloating
  • Nausea and Vomiting
  • Pain during Urination
  • Decrease of Urination
  • Swelling of the Legs and Feet
  • Swelling of the Throat or Tongue
  • Decrease in Urination
  • Chest Pain
  • Severe Pain in the Side and Back below the Ribs
  • Signs of Infection
  • Pink, Red, Brown, Cloudy, or Bad Smelling Urine
  • Peeling, Blistering, or Shedding Skin
  • Seizures

Other serious side effects are possible and the above is only a partial list. If you experience any side effects that you feel are concerning and serious it is always best to seek medical treatment immediately.


Ceftriaxone is contraindicated for patients with the following:

  • Clostridium Difficile Infection
  • Hemolytic Anemia
  • Severe Renal Impairment
  • Disease of the Gallbladder
  • Liver Problems
  • Yellowing of the Skin in a Newborn Child
  • Allergies to: Cephalosporins and/or Betalactams

Anyone who is breast-feeding or planning to breast-feed, pregnant, or planning a pregnancy should have a full consultation with their doctor before using ceftriaxone.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA