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Cefazolin is a cephalosporin antibiotic, a bacteria killer that physicians use to combat infections before, during, and after surgical procedures.

How to Use Cefazolin

Cefazolin is an injectable medication. Typically a patient will receive an injection at their physician's office, clinic, or hospital. If your physician orders a course of cefazolin for at home use it is important that you understand exactly how to use this drug so seek specific instructions on usage and delivery from a trained healthcare provider or your primary physician. Cefazolin should be only used as directed by your physician.

Possible Side Effects

Many possible side effects have been known to occur though it is important to note some patients may not experience side effects at all. Common side effects seen with cefazolin are as follows:

    Pain, Swelling, or Redness Near Site of Your Cefazolin Injection
  • White Patches in Mouth
  • Heartburn
  • Nausea or Vomiting
  • Headache
  • Confusion
  • Dizziness
  • Genital Itching
  • Heartburn
  • Gas
  • Diarrhea
  • Loss of Appetite
  • Tired Feeling
  • Weakness
  • Drowsiness

If any of the above or any other different side effects are experienced, monitor your condition. Seek medical assistance if you feel it is warranted or if any side effects are lingering or increasing in intensity.

Serious Side Effects:

Patients may experience serious side effects. Seek immediate medical treatment if you experience any of the serious side effects listed below, or other side effects that you feel are concerning or troublesome:

  • Rash or Hives
  • Difficulty Breathing
  • Difficulty Swallowing
  • Peeling Skin
  • Blistering Skin
  • Shedding Skin
  • Watery Stool
  • Bloody Stool
  • Stomach Cramps
  • Pain in Upper Right Stomach Area
  • Fever
  • Swelling (legs and feet especially)
  • Fainting
  • Signs of Infection
  • Dark Urine
  • Yellowing of Skin
  • Yellowing of Eyes


Do not use cefazolin if you have or have had:

  • Clostridium Difficile Infection
  • Moderate to Severe Kidney Impairment

Do not use cefazolin if you have allergies to the following:

  • Cephalosporins
  • Betalactams

Do not use cefazolin if you are pregnant, or about to become pregnant, breast-feeding or about to breast-feed unless you have first consulted with your physician and he or she has deemed the use of cefazolin to be necessary.

  • "It is rare to find health professionals who are so willing to educate the patient on what they need to know."

    Clair C. | West Hollywood, CA